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Glutathione is synthesized in two sequential enzymatic reactions: glutamate cysteine ligase (GCL) catalyzes the first, rate-limiting step, and glutathione synthetase couples -glutamylcysteine to glycine in the last step [13]

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Glutathione helps inhibit melanin production, while niacinamide and Vitamin C enhance brightness and improve overall skin clarity, targeting dull, yellow and red undertones

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As a consequence, a number of significant mechanisms and dynamic forces that determine regulatory pathways have been overlooked